Tape off the edges where the frame meets the glass of the photo frame with painter's tape or masking tape.
Wipe the glass with isospropyl alcohol.
Start using the alcohol inks dropping different colors on the glass.
Watch as the drops grow.
Add more color around and on top of the first drops.
Use a straw or can of air to blow the ink around in different directions.
Try spraying a little isospropyl alcohol to dispurse the color.
If you make a mistake or don't like something use a cotton pad with isopropyl alcohol or a cotton swap dipped in isopropyl alcohol to remove the ink.
Continue painting with the inks until you are satisfied with the results.
Let the ink dry before removing the painter's tape.
Once completely dry add a few thin coats of varnish in a matte or glossy finish.
Hang and enjoy.